Estrogen Receptor !, but Not ß, Is Required for Optimal Dendritic Cell Differentiation and Cd40-induced Cytokine Production Short Title: Estrogen Receptor ! Is Required for Optimal Dendritic Cell Development
نویسندگان
چکیده
*INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, F-31300, France; † INSERM, U858, Institut de Médecine Moléculaire de Rangueil, Toulouse, France; ‡ Université Paul Sabatier, Toulouse, F-31400 France; § Centre Hospitalier Universitaire, Toulouse, France; ¶ CNRS, UMR6101, Faculté de Médecine, Limoges, F-87025 France; ll IGBMC, CNRS-INSERM-ULP-Collège de France, Illkirch, F-67404 France.
منابع مشابه
Estrogen receptor alpha, but not beta, is required for optimal dendritic cell differentiation and [corrected] CD40-induced cytokine production.
Dendritic cells (DC) are critical actors in the initiation of primary immune responses and regulation of self-tolerance. The steroid sex hormone 17beta-estradiol (E(2)) has been shown to promote the differentiation of DCs from bone marrow (BM) precursors in vitro. However, the estrogen receptor (ER) involved in this effect has not yet been characterized. Using recently generated ERalpha- or ERb...
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